In AMD and other ocular diseases, the visual pigment cycle generate a by-product, which is an toxic aldehyde, called A2E. Its accumulation that leads to vision loss. We believe ELB00824 counteracts A2E effects by selective activation of the pathway of PPAR gamma responsible for:
- anti-oxidative activity (promoting anti-oxidant genes).
- anti-inflammatory activity (promoting anti-inflammatory genes).
- anti-apoptotic activity (enabling pathways that prevent cell death).
Our on-going studies found that the anti-oxidative, anti-inflammatory, and anti-apoptotic activities were also identified in other neurological diseases, e.g., Neuropathic Pain, Multiple Sclerosis (MS), Alzheimer’s disease (AD), and Diabetic Retinopathy.
We found ELB00824 inhibit production of both reactive oxygen species (ROS) and reactive nitrogen species (RNS), and it was proposed that they may interact directly with mitochondrial targets. Some mitochondrial targets have been identifified , such as complex I of the respiratory chain, MitoNEET (an iron transport protein), or MPC (mitochondrial pyruvate carrier).